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Manager, Clinical Portfolio Services, Business Operations

Alnylam Pharmaceuticals
paid time off
United States, Massachusetts, Cambridge
675 West Kendall Street (Show on map)
Dec 11, 2025
Overview

The Manager, Clinical Portfolio Services, Business Operations serves as a strong crossfunctionalpartner for financial and resourcing planning needs for Clinical Operations, aswell as direct support for Clinical Research Organizations (CROs) work order andcontract modification processes. This role works closely with the Director, ClinicalPortfolio Services, Business Operations and key stakeholders to follow tight financial
controls and is responsible for reporting, analytics, project management, andcoordination required to drive the business to efficient and effective financial and
resource management processes.

Key Responsibilities

  • In partnership with FP&A and Suppliers and Study Management, ensure accurate,transparent, and timely financial analyses to support Clinical Operationsaccruals; clearly articulate financial implications from variances betweenforecast and actuals and provide retrospective analysis as well as drive forwardactions for key business stakeholders. Supports Clinical Development ExpertiseAreas as needed
  • Support Clinical Operations budget, forecast and long-term planning.
  • Complete all required variance analyses for projects. Identify risks in the projectforecast and opportunities to improve revenue outlook. Communicate, documentand manage these on an ongoing basis.
  • Responsible for review of transparency reporting provided by CRO to ensurealignment with operation plan for study.
  • Develop and deliver training to support effective financial management processesthroughout the Clinical Operations organization. Supports Clinical DevelopmentExpertise Areas as needed.
  • Manage Purchase Orders (including entry and approval routing) and ChangeOrders for Clinical Trials
  • Contribute to continuous improvement and maintain a focus on value-addservices relating to resource planning and financial planning.

Key Skills

  • Knowledge of clinical operations process, understand concept of clinical trialsPhase I-III
  • Strong ability to manage and motivate colleagues in a matrix organization
  • Strong business acumen
  • Strong problem solving and analytical skills
  • Sound interpersonal, verbal and written communication skills
  • Commitment to and performs consistently high quality work
  • Ability to present eectively in a variety of settings
  • Ability to successfully work in a ('virtual`) team environment
  • Ability to identify and address issues proactively in a timely manner
  • Ability to take work independently
  • Comfort around senior management; effectively represents capabilities of team

Qualifications

  • BA/ BS in Operations, Science, Finance or Data Science required.
  • 5 years of progressive R&D Business Operations, Sourcing, or Finance/Resourcingroles, with strong analytical and partnering track record.
  • Strong experience in Pharma/CRO/Biotech, specifically with pricing models,supplier contracts and internal budget planning
  • Strong proficiency in Microsoft Excel (data manipulation) and PowerPoint(leadership presentations)
  • Demonstrated experience with Ariba, SAP, or other financial software is notrequired, but preferred

U.S. Pay Range

$120,700.00 - $163,300.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

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