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Executive Director, Head of NA Commercial Operations

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Dec 10, 2025

Job Description

General Summary:

The Executive Director (ED), North America Commercial Operations leads a team that supports multiple in-line disease areas, supporting each US Business Unit and their respective leadership teams within North America Commercial. The ED oversees 6 district functions: Commercial Data Management, Digital Customer Engagement, Field Operations, Marketing Operations, Field Training, and Business Engagement Leads.

This position reports to the Vice President, North America Commercial Operations, Insights & Analytics and is located at our headquarters in Boston, MA in the Seaport area.

Key Duties and Responsibilities:

  • Leads 6 distinct functions: Commercial Data Management, Digital Customer Engagement, Field Operations, Marketing Operations, Field Training, and business engagement leads in support of delivering on the North America Commercial objectives across multiple in-line disease areas
  • Partners with senior leaders across North America Commercial, DTE (IT), HR, Finance, and other key teams to translate business needs into proactive objectives that fuel commercial success
  • Ensures sales and marketing operational implementation effectiveness and efficiency
  • Enhances operational capabilities within team to support NA business in identifying opportunities to successfully support the business as a strategic partner
  • Leads team in supporting existing businesses and new launches for the NA Region including pre- and post-launch activities such as customer field mapping, incentive compensation planning, field force readiness and effectiveness, etc.
  • Understands Vertex business model, multiple disease areas, growth drivers, and supports creation of resourcing recommendations
  • Identifies future capabilities for novel business models to enable success in new disease areas
  • Works effectively with Legal, Medical, and Regulatory colleagues to ensure coordination of support in commercial adjacent functions achieve efficient and effective plans
  • As a people manager within the organization, may have financial accountabilities and human resource responsibilities for assigned staff
  • Collaborates on ad hoc business cases and other duties as needed

Knowledge and Skills:

  • Strong leadership qualities; demonstrated ability to lead, build and develop direct, indirect and cross-functional teams
  • Deep working knowledge of US Commercial Pharmaceutical Industry and the role that Commercial Operations plays within the organization
  • Experience in leading some combination of Field Operations, Digital Marketing, Marketing Operations and Field training teams
  • Demonstrated ability to develop innovative solutions, understands how to do the research to uncover missing information, and enjoys the challenge of being a solution architect
  • Leverages relationships, data, analytics and strategic mind-set in all aspects of supporting the NA commercial organization
  • Work effectively with internal stakeholders, external experts and support partners to assimilate leading insights to ensure in-line brands are successfully supported
  • Ability to work across disease areas and multiple (5+) Business Units
  • Demonstrated ability to think strategically and make sound recommendations to internal customers and cross-functional stakeholders
  • Proven ability to effectively manage ambiguity; can successfully cope with change, shift gears comfortably, decide and act without having the total picture
  • Exhibits outstanding written and oral communication skills, including the ability to effectively write and deliver presentations to professionals at all levels within Vertex
  • Excellent interpersonal skills to negotiate internally/externally often at higher levels and beyond

Education and Experience:

  • Bachelor's Degree in business, finance, quantitative major required. Advanced Degree/Masters and/or MBA in related field/majors desirable
  • Typically requires 10 years of experience in Commercial Pharmaceutical organization and/or Strategy/Management Consulting or the equivalent combination of education and experience
  • Experience in leading large multi-functional team of Commercial Operations professionals
  • Prior successful management of vendors and consultants
  • Experience with commercial drug launches, preferably in specialty
  • Experience in working within a matrixed organization

Pay Range:

$265,600 - $398,400

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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