Staff Research Associate III / Lab Manager - CAR T cell projects

Division of Hematology/Oncology

Full Time

82006BR

Job Summary

The Eyquem Laboratory is in need of a Research Associate /Lab Manager to assist with ongoing multidisciplinary CAR T cell projects. Our lab is interested in engineering next generation CAR T cell using the CRISPR/Cas9 system to enhance their activity, specificity, persistence and ultimately improve their therapeutic activity against solid tumor. We showed (Eyquem et al. Nature 2017) that targeting the CAR transgene to specific locus offers optimal CAR expression that prevents undesirable differentiation and exhaustion, which results in superior anti-tumor activity in hematological malignancies. These results greatly improved the understanding of CAR biology by establishing the first link between CAR expression and anti-tumor function. We are now applying these technologies to tackle solid tumor.

Our team includes clinical fellows in Hematology/Oncology, post-doctoral scientists in immunology, graduate students from the BMS program and research associates. Our work spans the fields of T cell immunology, CRISPR genetics and mouse tumor models. A unique collaborative environment involving groups at the Gladstone Institutes and multiple laboratories at UCSF creates a unique collaborative environment that is engaging, diverse and supportive.

Working as part of a multidisciplinary group, the SRA will utilize various protocols to generate the molecular components, such as DNA constructs, necessary for specific cellular engineering experiments. Additional responsibilities will consist of isolation and culture of primary human T cells, as well as functional analysis of engineered cells via Sanger sequencing, next-generation DNA sequencing, and flow cytometry. As a Lab Manager, the SRA will help with ordering, lab organization, biosafety and animal protocol maintenance.

Strong organizational and communication skills are required. For exceptionally skilled applicants, opportunity exists to extend the SRA's role to include the design and completion of cellular editing experiments, as well as in vivo analysis of novel cellular cancer immunotherapies. This position represents an excellent opportunity to gain exposure to basic laboratory skills as well as genetics and genome engineering skills in a dynamic, well-established research environment. This position will help aspiring graduate school or medical school candidates get the research experience and track record needed for a successful application and will foster career development through interactions with a wide variety of scientific researchers at UCSF.

Learn more about the Eyquem lab at https://profiles.ucsf.edu/justin.eyquem.

The final salary and offer components are subject to additional approvals based on UC policy.

Your placement within the salary range is dependent on a number of factors including your work experience and internal equity within this position classification at UCSF. For positions that are represented by a labor union, placement within the salary range will be guided by the rules in the collective bargaining agreement.

The salary range for this position is $30.89 - $49.68 (Hourly Rate).

To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html

Department Description

The Division of Hematology / Oncology is the largest Division in the Department of Medicine (DOM). Currently, the Division has 80+ Full-time faculty, 11 part-time and/or volunteer faculty, 29 Accreditation Council for Graduate Medical Education (ACGME) and non-ACGME fellows, 22 post-doctoral fellows, 32 Non-faculty appointments and 48 administrative and research staff. The Division's research, clinical and teaching functions are primarily split between the Parnassus and Mission Bay campuses, although the faculty, fellows, and staff have appointments and clinical, research, and educational activities at Zuckerberg San Francisco General (ZSFG), and Veterans Affairs Medical Center (VAMC) as well.

Required Qualifications

• Bachelor's degree in Biology, Molecular Biology or in a related science field and two or more years of recent, directly related work experience, utilizing the techniques or methods required by the position and demonstrating technical expertise in these areas; and/or equivalent experience/training.
• Prior experience working with biological samples
• Knowledge of scientific equipment (e.g. PCR machines, centrifuge, pipettes, liquid handling robotics)
• Lab safety training
• Blood-borne pathogen Training
• Biosafety training
• Computer skills including the use of Microsoft Word and Excel
• Ability to multi-task, prioritize and has superior organizational skill
• Excellent communication skills and demonstrated effective verbal and written communication skills
• Meticulous record keeping abilities
• Demonstrated record of excellent attendance and punctuality
• Careful attention to detail
• Flexible schedule - ability to work evenings and weekends

Preferred Qualifications

• Generally experienced in job duties and in the principles and practices associated with those duties with an understanding of the underlying scientific principles.
• Ability to draft routine reports and keep accurate records of work performed.
• Actively seeks opportunities to increase skills and expertise.
• Able to learn complex tasks with general instruction. Able to use experience to perform a variety of new techniques.

About UCSF

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world's leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

Pride Values

UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence - also known as our PRIDE values.

In addition to our PRIDE values, UCSF is committed to equity - both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at diversity.ucsf.edu

Join us to find a rewarding career contributing to improving healthcare worldwide.

Equal Employment Opportunity

The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.

Organization

Campus

Job Code and Payroll Title

009611 SRA 3

Job Category

Research and Scientific

Bargaining Unit

University Professional Technical Employees - Research Support Professionals Unit (UPTE-RX)

Employee Class

Career

Percentage

100%

Location

San Francisco, CA

Campus

Parnassus Heights (SF)

Work Style

Hybrid

Shift

Days, Variable

Shift Length

8 Hours

Additional Shift Details

Flexible schedule: ability to work evenings and weekends required by research duties